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Muscular dystrophy therapy via angiogenesis

Duchenne muscular dystrophy (DMD) is caused by mutations in a gene called dystrophin. Dystrophin maintains the structure and function of muscle fibers throughout the body and prevents damage caused by muscle contractions. Currently, there is no definitive treatment for DMD patients, and current therapies focus on prolonging survival and improving quality of life. This proposal attempts to reduce muscle fiber damage by promoting angiogenesis and vascular recovery, which may help in the development of new treatments for DMD through increased vascular density in blood-deficient dystrophic muscle.
Digital Object Identifier (DOI)
Grantee: Atsushi Asakura, PhD
Grant type: Research Grant
Award total: $300,000.00
Institution: Regents of the University of Minnesota - Twin Cities
Country: USA