The transition from pediatric to adult care is a challenging time for patients with neuromuscular disease and their families, as well as for providers. Increased use of disease-modifying treatments will likely lead to increased numbers of patients going through the transition process, and providers need to be aware of best practices to ensure this process is beneficial to all stakeholders. The first of this three-part series will examine the stages of transition of care, present common challenges and obstacles during transition, and recommended strategies and resources to ensure patients receive optimal care throughout this process.