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Repressing Adipogenesis in LGMD2B
Gradual replacement of functional muscle tissue with fatty infiltrates is a major driver of disease onset and progression in LGMD2B. We have identified the cells which cause this phenomenon and are now seeking methods to suppress their differentiation into adipocytes as a therapy for LGMG2B patients. In healthy muscle, there are physiological mechanisms that prevent the formation of lipid deposits after damage, but these appear to be lost in LGMD2B as the disease progresses and the muscle is replaced by fat. This proposal will unravel the causes of this phenomenon, and test methods to correct it which could be rapidly developed into therapies for patients.
Digital Object Identifier (DOI)
Grantee: Marshall Hogarth, Ph.D.
Grant type: Research Grant
Award total: $299,973.00
Institution: Children's Research Institute (CNMC)
Country: United States