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Grant - Summer 2019 - IBM - Bradley Olwin, PhD
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Bradley Olwin, PhD, professor of Molecular, Cellular, and Developmental Biology at the University of Colorado Boulder, was awarded an MDA research grant totaling $300,000 over three years to study the regulation of TDP-43 protein aggregates in normal and diseased skeletal muscle.
Over the past decade, the role of TDP-43 disregulation and aggregation in nerve cells in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) has become increasingly clear. In 1998, Dr. Olwin published work indicating TDP-43 had important roles in muscle cells as well.
This current grant funding will allow Dr. Olwin to build upon that novel work and study the dynamics of how TDP-43 myogranules (TDP-43-containing aggregates) form and dissolve in muscle cells normally, and in the context of diseases such as inclusion body myositis (IBM), an inflammatory myopathy. Understanding whether TDP-43 myogranules are functional or detrimental to muscle cells will be informative not just for IBM but also for other drug-development efforts focused on decreasing aggregation of TDP-43 (for example, in ALS and frontotemporal dementia).
https://doi.org/10.55762/pc.gr.87341
Grantee: IBM - Bradley Olwin, PhD
Grant type: Research Grant
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