Signs and Symptoms

The first symptoms of LEMS are usually leg weakness and difficulty walking. Oculobulbar weakness (affecting the muscles of the eyes, face and throat) may occur later, causing ptosis (droopy eyelids), speech impairment and swallowing problems.

Unlike weakness in myasthenia gravis, weakness in LEMS temporarily improves after exertion. For more on why this occurs, see Causes/Inheritance.

LEMS also sometimes causes autonomic (involuntary) symptoms such as dry mouth, constipation, impotence and bladder urgency.

Disease: