Amyotrophic Lateral Sclerosis (ALS)

ALS Risk Elevated in Some Retired NFL Players

Update (Nov. 6, 2012):This story was updated to reflect the availability of an abstract of the scientific paper (online and print) on which the story is based, as well as information about an upcoming webinar on this subject.

ALS and SMA: Less EPHA4 Means More Motor Neurons Survive

Decreased activity of the EPHA4 receptor, which is encoded by the EPHA4 gene, increases life span in people with amyotrophic lateral sclerosis (ALS), a team of scientists has reported.

The receptor, which was found to modify disease in zebrafish, mice, rats and humans, works together with a gene recently associated with ALS — profilin 1 (PFN1).  

Chemical 'Signature' May Be Used to Track ALS

A "pro-inflammatory" chemical signature displayed by monocytes (a type of white blood cell) appears to signal the presence of amyotrophic lateral sclerosis (ALS) even before symptoms begin, a team of scientists has reported. If verified, the blood biomarker may make it possible for physicians to monitor disease progression using a simple blood test.

MDA Commits $10.7 Million to Neuromuscular Disease Research

The Muscular Dystrophy Association has awarded 33 new grants totaling $10,684,481 to fund research projects focused on uncovering the causes of, and developing therapies for, neuromuscular disease.

MDA's Board of Directors reviewed and approved the new grants based on recommendations from the Association's Scientific and Medical Advisory Committees, and the grants took effect Aug. 1.

ALS: New MDA Grants Focus on Multisystem Aspects of the Disease

Three new MDA grants totaling $891,156 have been awarded to research projects aimed at uncovering some of the many complex processes that underlie ALS.

MDA Funds Efficacy Trial of Diaphragm Pacing System in ALS

The Muscular Dystrophy Association has committed $750,000 to help support a phase 2 clinical trial assessing the ability of the NeuRx Diaphragm Pacing System (DPS) to improve respiratory function and quality of life in people with amyotrophic lateral sclerosis (ALS).

'Repeats' in Normal C9ORF72 Gene Don't Affect ALS, FTD

Humans carry two copies of the C9ORF72 gene, each containing a stretch of DNA in which a sequence of DNA building blocks coded GGGGCC is repeated a number of times. (Each six-letter sequence is called a "repeat.")

When one of the two copies is mutated so that it contains a far greater than normal number of GGGGCC repeats (a repeat expansion mutation), it can cause some forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

Phase 3 Trial of Ceftriaxone in ALS Stopped

On Aug. 8, 2012, the National Institute of Neurological Disorders and Stroke (NINDS) reported that it has stopped a phase 3 clinical trial of the antibiotic ceftriaxone in amyotrophic lateral sclerosis (ALS) because the study was "unlikely to reach the predetermined efficacy criteria."

MDA Launches 'Bridge-to-Industry' Training Program

MDA launched its innovative Bridge-to-Industry (B2I) program with a $180,000 grant over three years to postdoctoral fellow Archi Joardar at The University of Arizona in Tucson, to develop two promising drug candidates for the treatment of amyotrophic lateral sclerosis (ALS).

MDA’s Bridge-to-Industry, or B2I, is a pilot project that trains promising researchers in translational research by providing experience both in academia and the biopharmaceutical industry.    

ALS — Marc Weisskopf, Sc.D., Ph.D.

MDA awarded a research grant totaling $301,614 over three years to Marc Weisskopf, associate professor of environmental and occupational epidemiology in the departments of environmental health and epidemiology at Harvard School of Public Health in Boston. The funds will help support Weisskopf’s search for nongenetic risk factors for amyotrophic lateral sclerosis (ALS).