For axons and Schwann cells, communication is the key to a healthy relationship. Axons send chemical messages that attract Schwann cells and encourage myelin formation, and Schwann cells appear to send messages that nourish and protect axons. The various genetic defects that cause CMT often disrupt these interactions.
The many different types of Charcot-Marie-Tooth (CMT) are distinguished by age of onset, inheritance pattern, severity, and whether they're linked to defects in axon or myelin.
While these distinctions are useful, it's important to realize that, because of the vast number of genetic defects that can lead to CMT, some people fall on the borders between different types and many have specific "subtypes" not detailed here.
Please click on the links below to learn more about these subtypes of CMT: