On the cover: Amy Dunaway-Haney of South Padre Island, Texas, was found to have limb-girdle MD at age 8 and began using a wheelchair in her teens. Now married, she teaches high school Spanish and has been nationally honored for her teaching and as the 2003 recipient of the MDA National Personal Achievment Award.

Dear Friends

What is Limb-Girdle Muscular Dystrophy?

What are the forms of limb-girdle muscular dystrophy?

How fast does LGMD progress?

What happens along the way?

What's not affected in LGMD?

What tests are used to diagnose LGMD?

Is it important to find out what genetic type of LGMD a person has?

Can special diets help in LGMD?

Are there any special exercises that can help?

Known Forms of Limb-Girdle Muscular Dystrophy

Does it Run in the Family?

MDA's Search for Treatments and Cures

MDA is Here to Help You

Known Forms of
Limb-Girdle Muscular Dystrophy

Type

Pattern of Inheritance

Gene or Chromosome

LGMD1A

Autosomal dominant

Myotilin gene

LGMD1B

Autosomal dominant

Lamin A/C gene

LGMD1C

Autosomal dominant

Caveolin gene

LGMD1D

Autosomal dominant

Chromosome 7

LGMD1E

Autosomal dominant

Chromosome 6

LGMD1F

Autosomal dominant

Chromosome 7

LGMD1G

Autosomal dominant

Chromosome 4

LGMD2A

Autosomal recessive

Calpain-3 gene

LGMD2B

Autosomal recessive

Dysferlin gene

LGMD2C

Autosomal recessive

Gamma-sarcoglycan gene

LGMD2D

Autosomal recessive

Alpha-sarcoglycan gene

LGMD2E

Autosomal recessive

Beta-sarcoglycan gene

LGMD2F

Autosomal recessive

Delta-sarcoglycan gene

LGMD2G

Autosomal recessive

Telethonin gene

LGMD2H

Autosomal recessive

TRIM32

LGMD2I

Autosomal recessive

FKRP gene

LGMD2J

Autosomal recessive

Titin gene

LGMD2K

Autosomal recessive

POMT1 gene

LGMD2L

Autosomal recessive

Fukutin gene