Quest Magazine

Scholarships for Caregivers

Four $2,500 scholarships — named in honor of a former MDA National Goodwill Ambassador — are being offered by the Rosalynn Carter Institute for Caregiving.  Deadline for applications is June 1.

The scholarships will provide financial assistance to family, professional, or paraprofessional caregivers of any age who are seeking training or education in specific skills, procedures and strategies that lead to more effective care and protect the health and well-being of the caregiver.

SOD1 Versus Other ALS: Apples and Oranges?

Scientists at Northwestern University Feinberg School of Medicine in Chicago have announced new findings showing some forms of familial and nonfamilial ("sporadic") amyotrophic lateral sclerosis (ALS) have commonalities at the molecular level — but that one form of familial ALS may be different.

DMD Research: New Funding for Imaging Studies

The use of magnetic resonance imaging (MRI) as an assessment tool in boys with Duchenne muscular dystrophy (DMD) is being studied by former MDA grantee Krista Vandenborne, through a $7.5 million grant from the National Institutes of Health (NIH).

The goal of the study is to assess whether MRI technology can be used as a precise, noninvasive measure of muscle tissue, gauging both disease progression and the effectiveness of therapies tested in children with DMD.

A Beach Park for EveryBODY

Designers of a new accessible beach park in Virginia Beach, Va., are very glad they asked Caroline Pennell, of Chesterfield, to look over their plans. The 14-year-old with limb girdle muscular dystrophy (LGMD) came up with the best idea of all. 

A Beach Park for EveryBODY

Designers of a new accessible beach park in Virginia Beach, Va., are very glad they asked Caroline Pennell, of Chesterfield, to look over their plans. The 14-year-old with limb girdle muscular dystrophy (LGMD) came up with the best idea of all. 

MTM: Unlocking Muscle Fibers to Myotubularin

MDA-supported researchers at 4s3 Bioscience, a biotechnology company in Medford, Mass., are using a new molecular strategy to transport a potentially therapeutic protein into muscles, as an experimental treatment for X-linked myotubular myopathy (MTM), a genetic muscle disease that's generally fatal in infancy.

The treatment will be tested in a mouse model of MTM. These mice do not make myotubularin and display signs and symptoms similar to those in humans with X-linked MTM.

"Anyone's Life Story" Shows Impact of ALS

ALS — a neuromuscular disease which can cause total paralysis and death within 5 years of diagnosis — often seems to come out of nowhere, striking active and athletic individuals in the prime of life.

ALS: Anyone’s Life Story,” MDA’s special feature for National ALS Awareness Month in May, makes the broad impact of this disease abundantly clear.

New Tools for Trials in Children with CMT

Two scales that can be used to assess disease progression and any response that may occur to a treatment have been developed for children with Charcot-Marie-Tooth (CMT) disease.

One, called the CMT Pediatric Scale, measures physical functioning. The second, called the Pediatric CMT Quality of Life Instrument, measures how the disease affects children's life experience. The two scales eventually will be merged, the investigators say.

Curcumin Helps Mice With CMT-Like Disease

Mice with a genetic mutation in the myelin protein zero (MPZ) gene, which develop a disease resembling human type 1B Charcot-Marie-Tooth disease (CMT1B), benefited from treatment with curcumin and curcumin derivatives, researchers announced April 15, at the 2010 meeting of the American Academy of Neurology (AAN), held in Toronto.

NT3 Gene Therapy for CMT1A Benefits Mice

Mice with a disorder resembling type 1A Charcot-Marie-Tooth (CMT1A) disease that received a single intramuscular injection of genes for the protein neurotrophin 3 (NT3) showed improvements in grip strength, ability to stay on a rotating rod, and strength of nerve signals, investigators reported April 15, at the 2010 meeting of the American Academy of Neurology, held in Toronto.

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