Quest Magazine

US Team Wins PowerHockey Cup

It didn’t look good for the Minnesota Saints.

Playing against the tough Michigan Mustangs for the top prize in power wheelchair hockey, the Saints went up 4-2, only to see the score tied 4-4 with just five minutes to go.

That’s when forward Chad Wilson, 21, of Chanhassen, Minn., went into overdrive. Wilson, who has Becker muscular dystrophy (BMD), took less than two minutes to score two more goals for the Saints.

Research Briefs: ALS, BMD, DMD, MMD, SMA, Muscle Regeneration

Amytrophic lateral sclerosis (ALS)

Not One But Two DNA Changes Are Needed to Cause FSHD

Facioscapulohumeral muscular dystrophy (FSHD) requires the presence of not one but two genetic changes, both on chromosome 4, before it causes its characteristic symptoms — weakness starting in the muscles of the face, shoulder blade area and upper arms, with possible progression to other parts of the body.

The new findings, announced online Aug. 19, 2010, in the journal Science, have immediate implications for diagnosis and prediction of FSHD, and possible long-term implications for its treatment.

ALS Experts Urge Caution Regarding Head Injury Findings

A new study has claimed professional athletes who have sustained repeated head injuries and developed what's known as "chronic traumatic encephalopathy" (CTE) may also be at higher-than-average risk for developing a motor neuron disease that resembles amyotrophic lateral sclerosis (ALS) or is a subtype of ALS.

The two diseases may be part of a continuum of nervous-system pathology that can start with repeated head trauma and ultimately involve the brain and spinal cord, resulting in cognitive, behavioral and motor abnormalities, the study's investigators say.

MDA Awards More Than $14 Million in Research Grants

MDA has awarded 38 new research grants totaling more than $14 million and covering more than a dozen neuromuscular diseases. 

MDA's Board of Directors met in Los Angeles July 16, where it reviewed and approved the new grants based on recommendations from the MDA Scientific and Medical Advisory Committees. Grants were scored and recommended for approval based on the capabilities of the applicant, the scientific merit of the project, and the proposal's relevance to developing treatments for the disease. The effective start date for all grants was July 1, 2010.

MDA Awards Nearly $3.5 Million in New ALS Grants

MDA has awarded 10 grants totaling nearly $3.5 million to fund research projects focused on uncovering the causes of, and developing therapies for, ALS.

The new grants went to investigators at labs in the United States, Canada and Israel.

More FUS-Related ALS Cases Found

Mutations in the gene for a protein called FUS may be a more widely distributed cause of amyotrophic lateral sclerosis (ALS) than previously recognized, according to three separate reports, all published in July 2010 in the journal Neurology.

Research Briefs: ALS, DMD, MTM and SMA

Duchenne muscular dystrophy

Acceleron Pharma announced Aug. 4 that it has received fast track designation from the U.S. Food and Drug Administration (FDA) for its experimental compound ACE031 for the treatment of Duchenne muscular dystrophy (DMD). ACE031 is designed to interfere with the actions of myostatin, a protein that inhibits muscle growth.

Blocking a Protein Extends Survival in ALS Mice

Elevated levels of an immune-system protein called interleukin-1-beta (IL-1-beta) exacerbates a disease in mice that closely resembles human amyotrophic lateral sclerosis (ALS), and blocking this protein extends survival in these mice, a research team in Germany has found.

The study adds to the accumulating evidence that the immune system misbehaves in ALS and that altering its behavior could be a way to treat the disease.

Feds Both Seek and Give Advice Re Disability Issues

Two federal agencies are seeking to improve conditions for people with disabilities, in one case by strengthening federal hiring regulations, and in the other by making health care facilities more accessible to people with mobility problems.

Improving employment

The U.S. Department of Labor, through its Office of Federal Contract Compliance Programs (OFCCP), is inviting public comments on ways to strengthen regulations covering the hiring of people with disabilities by federal contractors.

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