Peroneal Muscular Atrophy (Charcot-Marie-Tooth Disease)

CMTX

What is Charcot-Marie-Tooth disease type X (CMTX)?

CMTX is a subtype of CMT, a genetic, neurological disorder that causes damage to the peripheral nerves — tracts of nerve cell fibers that connect the brain and spinal cord to muscles and sensory organs.

CMT1-CMT2

What are Charcot-Marie-Tooth disease type 1 (CMT1) and type 2 (CMT2)?

These are the two most common forms of CMT, a genetic, neurological disorder that causes damage to the peripheral nerves — tracts of nerve cell fibers that connect the brain and spinal cord to muscles and sensory organs.

A subtype of CMT1, called CMT1A (caused by a defect in the PMP22 gene on chromosome 17) accounts for around 60 percent of all CMT cases.

Types of CMT

For axons and Schwann cells, communication is the key to a healthy relationship. Axons send chemical messages that attract Schwann cells and encourage myelin formation, and Schwann cells appear to send messages that nourish and protect axons. The various genetic defects that cause CMT often disrupt these interactions.

The many different types of Charcot-Marie-Tooth (CMT) are distinguished by age of onset, inheritance pattern, severity, and whether they're linked to defects in axon or myelin.

Overview

What is Charcot-Marie-Tooth disease (CMT)?

Illustration of systems affected by CMT
CMT causes degeneration of the peripheral nerves, leading to muscle weakness in the body’s extremities.

Charcot-Marie-Tooth Disease

Description: 

MDA leads the search for treatments and therapies for Charcot-Marie-Tooth disease (CMT). The Association also provides comprehensive supports and expert clinical care for those living with CMT.

In this section, you’ll find up-to-date information about Charcot-Marie-Tooth disease, as well as many helpful resources. This information has been compiled with input from researchers, physicians and people affected by the disease.

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